DRUGS AND DRIVINGDRUGS AND DRIVING
It is a known fact that illicit drugs and alcohol are predominant in drugs’ associated with road traffic accidents, but a number of prescribed drugs also contribute to injuries and deaths.
Although if taken as prescribed and instructed, there may be no injuries or fatalities, due to the use of drugs, still, a number of prescribed drugs (used correctly or not) impair the ability to drive.
Creating awareness among prescribers, dispensers and patients is therefore paramount.
REQUIREMENTS IN DRIVING
Both cognitive and psychomotor skills are the two main requirements of the body to drive safely and competently after learning the skill.
While the ability to make appropriate decisions relates to cognitive skills, psychomotor skills include reaction times and hand-eye coordination.
In other words, the most important skills required for safe driving are vigilance, ability to interpret traffic situations and to divide attention between tasks.
The driver's behaviour and attitude also contribute to the risk of having an accident, just as attentiveness and concentration, vigilance, divided attention skills (performing two or more functions simultaneously), visual fields and acuity, limb-eye (hand-eye and foot-eye) coordination, reaction time as well as ability to maintain lane control (tracking).
Drugs can also affect a number of brain functions that adversely influence the ability to drive safely.
BRAIN ACTIVITIES AND DRUGS
A large range of substances are known to impair the cognitive or psychomotor skills required for safe driving.
Any drug acting on the central nervous system has the potential to adversely affect driving skills.
Central nervous system depressants reduce vigilance, increase reaction times and increase errors associated with decision making and speed control in a very similar manner to alcohol.
Drugs that affect behaviour may exaggerate adverse behavioural traits and risk-taking behaviour.
Special mention must be made of alcohol and illicit drugs.
Alcohol continues to be the most prevalent drug causing road trauma.
The average blood alcohol concentration in fatal accidents is over 0.15%.
Cannabis (marijuana), amphetamine-type stimulants and opioids are the others.
Taking drugs with alcohol increases impairment of driving skills.
During the acute phase of activity, central nervous system stimulants such as the amphetamines and cocaine tend to reduce performance on divided attention tasks, cause tunnel vision and increase risk taking.
They can also cause rebound fatigue, inattention and hyper-somnolence when the stimulatory effects wear off.
Prescribed drugs also impair cognitive and psychomotor skills.
However, with the exception of benzodiazepines, the evidence for the role of prescribed drugs in road trauma is uncertain.
In general, most drugs tend not to be significant risk factors on the road when the drugs are used as prescribed.
Some drugs can cause impairment due to their central nervous system depressant properties, particularly early in treatment before the patient becomes accustomed to the drug, or when the drug is misused.
The most common examples seen in road trauma are the anticonvulsants and the antidepressants, but their presence does not necessarily mean that they had a contribution to the crash.
In many cases two or more impairing drugs including alcohol are detected.
Combinations of drugs increase the opportunity for impairment and the risk of a serious crash.
Antidepressants
Antidepressants are double-edged.
While they can reduce the psychomotor and cognitive impairment caused by depression and return mood towards normal, thus improving driving performance, some of them are sedating (tricyclic antidepressants, typified by amitriptyline and dothiepin).
The ability to impair is greater with sedating, than with the less sedating serotonin reuptake inhibitors.
Antipsychotics
This diverse class of drugs can improve performance if substantial psychotic-related cognitive deficits are present.
However, most antipsychotics are sedating and have the potential to adversely affect driving skills through blockade of central dopaminergic and other receptors.
Older drugs such as chlorpromazine are very sedating due to their additional actions on the cholinergic and histamine receptors.
Some newer drugs are also sedating, such as clozapine, olanzapine and quetiapine, while others such as aripiprazole, risperidone and ziprasidone are less sedating.
Sedation may be a particular problem early in treatment and at higher doses.
Benzodiazepines
Obviously for hypnotic / sedative properties, benzodiazepines are well known to increase the risk of a crash.
They are found in about 4% of fatalities and 16% of injured drivers taken to hospitals.
In many of these cases, benzodiazepines were either abused or used in combination with other impairing substances.
The illicit trade in these drugs is significant and they are often obtained by “under-the-counter” (UTC), “behind-the-counter” (BTC) or “doctor shopping”.
Prescribers do need to be aware of this possibility when prescribing benzodiazepines and the related hypnotics zolpidem and zopiclone.
If a hypnotic is needed, a shorter-acting drug is preferred.
Tolerance to the sedative effects of the longer-acting benzodiazepines used in the treatment of anxiety gradually reduces their adverse impact on driving skills.
Opioids
There is little direct evidence that opioid analgesics such as hydromorphone, morphine or oxycodone have direct effects on driving behaviour.
Cognitive performance is reduced early in treatment, largely due to their sedative effects, but neuro-adaptation rapidly sets in.
This means that patients on a stable dose of an opioid may have a less risk of an accident.
This includes patients on buprenorphine and methadone for their opioid dependency, providing the dose has been stabilised after some weeks and they are not abusing other impairing drugs.
Driving at night may be a problem due to the persistent miotic effects of these drugs reducing peripheral vision.
Drugs for diabetes
Hypoglycaemia , which translates into less glucose reaching the brain, can be a significant problem.
The drugs themselves have no major effect on skills, but how well they control blood glucose will affect driving performance.
MEDICINES THAT MAY IMPAIR DRIVING SKILLS
Anticonvulsants (carbamazepine, gabapentin, phenobarbitone, phenytoin, valproate, vigabatrin, etc.)
Antihistamines
- sedating (azatadine, chlorpheniramine, cyproheptadine, diphenhydramine, promethazine, doxylamine, trimeprazine, etc.)
- less sedating (cetirizine, desloratidine, fexofenadine, loratidine, etc.)
Antipsychotics (amisulpride, chlorpromazine, haloperidol, pericyazine, clozapine, olanzapine, etc.)
Benzodiazepines and related compounds (temazepam, lorazepam, nitrazepam, oxazepam, alprazolam, clonazepam, diazepam, zolpidem, zopiclone, etc.)
Drugs for diabetes
Muscle relaxants (baclofen, dantrolene, orphenadrine, etc.)
Opioid analgesics (codeine, buprenorphine, methadone, morphine, oxycodone, pethidine, tramadol, etc.)
Serotonin reuptake inhibitors and reversible monoamine oxidase inhibitor antidepressants (fluoxetine, sertraline, paroxetine, citalopram, venlafaxine, moclobemide, etc.)
Tricyclic and tetracyclic antidepressants (amitriptyline, clomipramine, dothiepin, doxepin, imipramine, trimipramine, mianserin, mirtazapine, etc.)
Sympathomimetics (pseudoephedrine, phenylephedrine, etc.)
THE ROLES OF THE PHARMACIST
Adequate counselling of patients is very important.
Patients should be warned about the dangers of driving a motor vehicle early in treatment with the drugs that can affect driving.
The pharmacist may additionally label the caution (as auxiliary labels) if the product information of the drug does not contain a precaution about driving.
Patients driving at night or working shifts where normal sleep patterns are altered are also at an increased risk of fatigue-related crashes.
Many drugs can exacerbate the effects of sleep deprivation and increase the risk of a crash.
References
1. Burns M, editor. Medical-legal aspects of drugs. 2nd ed. Tucson (AZ): Lawyers & Judges Publishing Company; 2007.
2. Drummer OH, Gerostamoulos J, Batziris H, Chu M, Caplehorn JR, Robertson MD, et al.The incidence of drugs in drivers killed in Australian road traffic crashes. Forensic Sci Int 2003;134:154-62.
3. Ch'ng CW, Fitzgerald M, Gerostamoulos J, Cameron P, Bui D, Drummer OH, et al.
Drug use in motor vehicle drivers presenting to an Australian, adult major trauma centre. Emerg Med Australas 2007;19:359-65.
4. Bramness JG, Skurtveit S, Morland J. Testing for benzodiazepine inebriation - relationship between benzodiazepine concentration and simple clinical tests for impairment in a sample of drugged drivers. Eur J Clin Pharmacol 2003;59:593-601.
5. Drummer OH, Gerostamoulos J, Batziris H, Chu M, Caplehorn J, Robertson MD, et al.The involvement of drugs in drivers of motor vehicles killed in Australian road traffic crashes. Accid Anal Prev 2004;36:239-48.
6. Ramaekers JG, Berghaus G, van Laar M, Drummer OH. Dose related risk of motor vehicle crashes after cannabis use. Drug Alcohol Depend 2004;73:109-19.
7. Drummer OH. Benzodiazepines - effects on human performance and behaviour. Forensic Sci Rev 2002;14:1-14.
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